BDBM139545 US8889870, 5::US9388176, 5::US9820989, 5

SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=PRIKAWGHFGEEJC-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 139545   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM139545(US8889870, 5 | US9388176, 5 | US9820989, 5)
Affinity DataKi:  12nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM139545(US8889870, 5 | US9388176, 5 | US9820989, 5)
Affinity DataKi:  26nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM139545(US8889870, 5 | US9388176, 5 | US9820989, 5)
Affinity DataIC50:  26nMpH: 7.4 T: 2°CAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM139545(US8889870, 5 | US9388176, 5 | US9820989, 5)
Affinity DataIC50:  47nMpH: 7.4Assay Description:Biochemical PDGFR.beta. kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 .mu.g of poly-Glu-Tyr (4:1) in 1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM139545(US8889870, 5 | US9388176, 5 | US9820989, 5)
Affinity DataIC50:  19nMpH: 7.4Assay Description:Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 .mu.g/well of poly-Glu-Tyr (4:1) in 10 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Allergan

US Patent
LigandPNGBDBM139545(US8889870, 5 | US9388176, 5 | US9820989, 5)
Affinity DataIC50:  12nMpH: 7.4 T: 2°CAssay Description:Biochemical KDR kinase assays were performed in 96 well microliter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...More data for this Ligand-Target Pair
In DepthDetails US Patent