BDBM14155 APC-7136::CHEMBL64708::N-(4-CARBAMIMIDOYL-PHENYL)-2-HYDROXY-BENZAMIDE::N-(4-carbamimidoylphenyl)-2-hydroxybenzamide

SMILES NC(=N)c1ccc(NC(=O)c2ccccc2O)cc1

InChI Key InChIKey=MYHDBRFFPZXDMX-UHFFFAOYSA-N

Data  11 KI  2 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 14155   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibition of urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  3.20E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  3.80E+3nM ΔG°:  -7.31kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetPlasminogen(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  6.60E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  1.00E+4nMAssay Description:Activation of tissue plasminogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  1.20E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  1.20E+4nMAssay Description:The compound was evaluated to inhibit the Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  2.30E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  2.40E+4nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataKi:  9.00E+4nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of recombinant human N-terminal his-tagged KLK1 (19 to 262 residues) expressed in baculovirus infected sf9 insect cells using R110 labelle...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKallikrein-5(Homo sapiens (Human))
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM14155(APC-7136 | CHEMBL64708 | N-(4-CARBAMIMIDOYL-PHENYL...)
Affinity DataIC50:  6.31E+3nMAssay Description:Inhibition of recombinant human FLAG-tagged KLK5 expressed in baculovirus infected sf9 insect cells using (Tos-Gly-Pro-Arg)2[R110].2TFA as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed