BindingDB BDBM168301 US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-8′-chloro-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione (Cpd. No. 127)::US9669031, 145 6′-((1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-8′-chloro-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione (Cpd. No. 145)

BDBM168301 US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-8′-chloro-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione (Cpd. No. 127)::US9669031, 145 6′-((1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)-8′-chloro-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione (Cpd. No. 145)

SMILES Clc1cc(Nc2ncnc3[nH]ncc23)c(=O)n2c1C(=O)NC21CCCCC1

InChI Key InChIKey=RWALTXNCWCAKGV-UHFFFAOYSA-N

Data 4 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 168301

MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Effector Therapeutics

US Patent

BDBM168301(US9669031, 127 6′-((1H-pyrazolo[3,4-d]pyrimi...)

IC50: <10nMT: 2°CAssay Description:Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid

Details US Patent

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Effector Therapeutics

US Patent