BDBM195879 US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-phenylamino)-7-oxo-8(7H)-pteridin-yl)phenyl) acrylamide

SMILES CC(=O)Nc1ccc(Nc2ncc3ncc(=O)n(-c4cccc(NC(=O)C=C)c4)c3n2)cc1

InChI Key InChIKey=JIJDVLXBQGQRQM-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 195879   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University of Science and Technology

US Patent
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  16nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
East China University of Science and Technology

US Patent
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  13nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
East China University of Science and Technology

US Patent
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  5.12nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
East China University of Science and Technology

US Patent
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  148nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  5.45E+3nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 (564 to 993 residues) expressed in baculovirus expression system using peptide FAM-P2 as substrate inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  14nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
East China University of Science and Technology

US Patent
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  13nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195879(US9670213, Compound 024 N-(3-(2-(4-(acetylamino)-p...)
Affinity DataIC50:  3.55E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent