BDBM202380 US10081606, Compound I-12::US9238629, I-12::US9765038, Compound I-12

SMILES COc1ccccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1

InChI Key InChIKey=DSRXZMGDJDQWJM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 202380   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US10081606, Compound I-12 | US9238629, I-12 | US97...)
Affinity DataIC50:  650nMpH: 7.5 T: 2°CAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US10081606, Compound I-12 | US9238629, I-12 | US97...)
Affinity DataIC50: <1nMpH: 7.5 T: 2°CAssay Description:Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13x ATP (AS001A) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-249,301-1210,T790M,L858R](Homo sapiens (Human))
Celgene Car

US Patent
LigandPNGBDBM202380(US10081606, Compound I-12 | US9238629, I-12 | US97...)
Affinity DataIC50: <1nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US10081606, Compound I-12 | US9238629, I-12 | US97...)
Affinity DataIC50: <1nMpH: 7.5Assay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US10081606, Compound I-12 | US9238629, I-12 | US97...)
Affinity DataIC50:  650nMAssay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celgene Avilomics Research

US Patent
LigandPNGBDBM202380(US10081606, Compound I-12 | US9238629, I-12 | US97...)
Affinity DataIC50:  650nMpH: 7.5Assay Description:The mechanics of the assay platform are best described by the vendor (Invitrogen, Carlsbad, Calif.) on their web site at the following URL: www.invit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent