BDBM220192 US9290476, 35A::US9290476, 35B::US9290476, 35C

SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F

InChI Key InChIKey=LZOGZAYEBDXEJA-UHFFFAOYSA-N

Data  4 IC50  6 Kd

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 220192   

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataKd:  8nMpH: 7.0 T: 2°CAssay Description:Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataKd:  70nMpH: 7.0 T: 2°CAssay Description:Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataKd:  5nMpH: 7.0 T: 2°CAssay Description:Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataIC50:  89nMAssay Description:Compound was evaluated for binding affinity by the inhibition of Glutamine synthetase (Ovine brain) activity using biosynthetic assay [competitive in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataKd:  5nMAssay Description:Displacement of 1,8-ANS from human N-terminal His-tagged RORgammat LBD (850 to 1635 residues) expressed in Escherichia coli by thermofluor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataIC50:  57nMAssay Description:Inverse agonist activity at RORgammat in human Th17 cells assessed as inhibition of IL17A productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataKd:  5nMAssay Description:Displacement of 1,8-ANS from human N-terminal His-tagged RORgammat LBD (850 to 1635 residues) expressed in Escherichia coli by thermofluor assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataIC50:  89nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataIC50:  89nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220192(US9290476, 35A | US9290476, 35B | US9290476, 35C)
Affinity DataKd:  5nMAssay Description:Displacement of 1,8-ANS from recombinant human RORgammat LBD expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of co-activator SR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB