BDBM25082 3-(2,4-diamino-pteridin-6-yl)-phenol::3-(2,4-diaminopteridin-6-yl)phenol::JMC504279 Compound 17::TG100713

SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1

InChI Key InChIKey=UOORQSPLBHUQDQ-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25082   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Targegen

LigandBDBM25082(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)Copy SMILESCopy InChI

Affinity DataIC50:  50nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
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LigandBDBM25082(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)Copy SMILESCopy InChI

Affinity DataIC50:  24nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Targegen

LigandBDBM25082(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)Copy SMILESCopy InChI

Affinity DataIC50:  39.9nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Targegen

LigandBDBM25082(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)Copy SMILESCopy InChI

Affinity DataIC50:  215nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

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In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Targegen

LigandBDBM25082(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)Copy SMILESCopy InChI

Affinity DataIC50:  165nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI