BDBM251588 US9453031, 11

SMILES CNc1nc2ccccc2n1-c1nc2N3CCOC[C@H]3COc2c(n1)C(C)(C)S(C)(=O)=O

InChI Key InChIKey=JEWXHIMACGOZFL-ZDUSSCGKSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 251588   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50:  1.90E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#33-016), which is a homogeneous assay to me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR [1360-2549](Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50:  604nMpH: 7.5 T: 2°CAssay Description:The enzymatic mTOR activity was measured using a LanthaScreen kinase activity assay (Invitrogen). The enzyme was purchased from Invitrogen (PV4754), ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50:  1.51E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was measured by using the commercial ADP Hunter Plus assay available from DiscoveRx (#90-0083), which is a homogeneous assay to m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50:  4.00E+6nMAssay Description:Predictor hERG Assay test kits were obtained from Invitrogen (Carlsbad, Calif.). The binding assay was carried out according to the kit instructions....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50:  3.90E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: >5.00E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50:  3.40E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: >5.00E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
FundacióN Centro Nacional De Investigaciones OncolóGicas Carlos Iii

US Patent
LigandPNGBDBM251588(US9453031, 11)
Affinity DataIC50: >5.00E+4nMT: 2°CAssay Description:Five CYP isoforms (0.5 pmol) were tested, namely 1A2, 2C9, 2C19, 2D6 and 3A4 (each isoform was assayed in a separate assay plate). Each assay plate c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent