BDBM259849 US9505766, 53
SMILES Nc1ncnc2n(cc(-c3ccc(Cl)cc3)c12)-c1cccc(\C=C(/C#N)C(=O)N2CCC2)c1
InChI Key InChIKey=LEQFDZQGIRPRQW-WOJGMQOQSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 259849
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [S345C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: 2.50E+3nMpH: 7.4 T: 2°CAssay Description:Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataIC50: >5.00E+3nMpH: 7.4 T: 2°CAssay Description:Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin...More data for this Ligand-Target Pair