BDBM259897 US9505780, JQ-1

SMILES Cc1nnc2[C@@H](N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1)C(=O)OC(C)(C)C

InChI Key InChIKey=DOXYOPGGFSMXOX-GOSISDBHSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 259897   

TargetBromodomain-containing protein 4 [75-147](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259897(US9505780, JQ-1)
Affinity DataIC50:  27.1nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [368-440](Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259897(US9505780, JQ-1)
Affinity DataIC50:  39.1nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
West China Hospital Of Sichuan University

Curated by ChEMBL
LigandPNGBDBM259897(US9505780, JQ-1)
Affinity DataIC50:  92nMAssay Description:Inhibition of His-tagged full length recombinant BRD4 (unknown origin) (21 to 153 residues) using SGRGK(Ac)GGK(Ac)GLGK(Ac)GGAK(Ac)RHRK(Biotin)-OH as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259897(US9505780, JQ-1)
Affinity DataIC50: >5.00E+4nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259897(US9505780, JQ-1)
Affinity DataIC50: >5.00E+4nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM259897(US9505780, JQ-1)
Affinity DataIC50: >5.00E+4nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent