BDBM263675 5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-6-(1H- indol-5-yl)- 8,9-dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 12

SMILES Oc1ccc2c(CCCC(c3ccc4[nH]ccc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1

InChI Key

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 263675   

TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263675(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263675(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataEC50:  0.5nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 4 hrs by Alexafluor-488 conjugate anti-rabbit antibody/Syto-64 staining based immu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263675(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [D538G](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263675(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  18nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent