BDBM273181 (R)-1-(5-oxo-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-2-yl)-N-(1-phenylcyclopropyl)pyrrolidine-2-carboxamide::US10065972, Example 655

SMILES O=C(NC1(CC1)c1ccccc1)[C@H]1CCCN1c1nn2c(nc3ccccc3c2=O)s1

InChI Key InChIKey=LXGGDHADSBPRMB-GOSISDBHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273181   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273181((R)-1-(5-oxo-5H-[1,3,4]thiadiazolo[2,3-b]quinazoli...)
Affinity DataIC50:  29nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent