BDBM277161 (S) or (R)-4-[1- (difluoromethyl)-1H- pyrazol-4-yl]-7-{(1R)-1-[2- (trifluoromethyl)pyridin-4- yl]ethyl}-5,6,7,8- tetrahydro-1,7- naphthyridine-2- carboxamide::US10072003, Example 7-3A::US10072003, Example 7-3B

SMILES CC(N1CCc2c(C1)nc(cc2-c1cnn(c1)C(F)F)C(N)=O)c1ccnc(c1)C(F)(F)F

InChI Key InChIKey=YDSFBDJOIPTAED-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277161   

TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM277161((S) or (R)-4-[1- (difluoromethyl)-1H- pyrazol-4-yl...)
Affinity DataIC50:  2.12E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM277161((S) or (R)-4-[1- (difluoromethyl)-1H- pyrazol-4-yl...)
Affinity DataIC50:  2.93E+4nMAssay Description:The utility of the compounds of the invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR2 activity, may be demon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent