BDBM277376 US10072025, Example 3-10::tert-butyl 4-ethyl-4-(3-{[3- methyl-4-(1,4-oxazepan-4- ylcarbonyl) phenyl]amino}-4-oxo-4,5- dihydro-1H-pyrazolo[4,3- c] pyridin-1-yl) piperidine- 1-carboxylate

SMILES CCC1(CCN(CC1)C(=O)OC(C)(C)C)n1nc(Nc2ccc(C(=O)N3CCCOCC3)c(C)c2)c2c1cc[nH]c2=O

InChI Key InChIKey=IDKLSHNSHBCUFM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 277376   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277376(US10072025, Example 3-10 | tert-butyl 4-ethyl-4-(3...)
Affinity DataIC50:  0.430nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM277376(US10072025, Example 3-10 | tert-butyl 4-ethyl-4-(3...)
Affinity DataIC50:  0.290nMT: 2°CAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent