BDBM278554 (2E)-[1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(2-fluoropropan-2-yl)-1,2-oxazol-4-yl]carbonyl}-3,4-dihydrobenzo[cd]indol-5(1H)-::US10040791, Example 16

SMILES CC(C)(F)c1onc(c1C(=O)n1cc2CC\C(=C/C(O)=O)c3cccc1c23)-c1c(F)cc(Cl)cc1Cl

InChI Key InChIKey=KKYRFHWXZPWGSG-XYOKQWHBSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 278554   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278554( (2E)-[1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(2-fl...)
Affinity DataIC50:  107nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM278554( (2E)-[1-{[3-(2,4-Dichloro-6-fluorophenyl)-5-(2-fl...)
Affinity DataIC50:  15nMpH: 7.5 T: 2°CAssay Description:The IDH1R132H protein and the IDH1R132C protein were prepared as follows: the IDH1R132H or IDH1R132C gene was integrated into a pET24b(+) vector (Nov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent