BDBM278987 5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimidazol-2-yl)methyl]pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 17::US10512632, Example 17::US10618913, Example S17::US10766893, Example S17::US10806718, Example 17::US11026923, Example 17::US11491140, Example 17::US11634416, Example 17

SMILES CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C

InChI Key InChIKey=XRIYYPDCPKIHRW-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 278987   

LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  700nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  970nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  970nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  700nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  54nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  970nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  700nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  54nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  970nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  700nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  54nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  970nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  700nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  54nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  970nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  700nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  54nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  970nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  700nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  54nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  970nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  700nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  54nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM278987(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Affinity DataIC50:  54nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent