BDBM279171 1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)-5-(4-methyloxazol-2-yl)-1H-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 202::US10512632, Example 202::US10766893, Example S202::US10806718, Example 202::US11634416, Example 202

SMILES CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nc(C)co1

InChI Key InChIKey=GNUZZRWHGHQDMA-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 279171   

LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  92nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  170nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  92nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  92nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  92nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  170nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  92nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279171(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  14nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent