BDBM285672 US10077273, Compound HK-2::US10934305, Compound HK-2

SMILES COc1cccc(c1)C1(C2CCC2)c2c(C)n[nH]c2OC(N)=C1C#N

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 285672   

TargetSerine hydroxymethyltransferase, mitochondrial(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285672(US10077273, Compound HK-2 | US10934305, Compound H...)
Affinity DataIC50: >5.00E+3nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine hydroxymethyltransferase, mitochondrial(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285672(US10077273, Compound HK-2 | US10934305, Compound H...)
Affinity DataIC50: >5.00E+3nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine hydroxymethyltransferase, cytosolic(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285672(US10077273, Compound HK-2 | US10934305, Compound H...)
Affinity DataIC50: >5.00E+3nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine hydroxymethyltransferase, cytosolic(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285672(US10077273, Compound HK-2 | US10934305, Compound H...)
Affinity DataIC50: >5.00E+3nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent