BDBM288879 US10092563, Compound 14

SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2[C@@H]2[C@H]3CNC[C@@H]23)c1C#N

InChI Key InChIKey=IJBKSHRETAMTRG-QABNGEJJSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 288879   

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM288879(US10092563, Compound 14)
Affinity DataIC50:  400nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM288879(US10092563, Compound 14)
Affinity DataIC50:  4.80E+5nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM288879(US10092563, Compound 14)
Affinity DataIC50:  300nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent