BDBM28977 2-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl}methane)sulfonyl]pyridine::cyclohexyl sulfone-based compound, 21
SMILES Fc1ccc(F)c(c1)[C@]1(CC[C@H](CS(=O)(=O)c2ccccn2)CC1)S(=O)(=O)c1ccc(Cl)cc1
InChI Key InChIKey=BNRCMKYOGYXWND-SMQSCJQKSA-N
Data 1 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 28977
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit PEN-2/Nicastrin [34-709]/Presenilin-1(Homo sapiens (Human))
Merck Research Laboratories
Merck Research Laboratories
Affinity DataEC50: 2.10nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair