BDBM290112 US9573961, Example 97

SMILES Cc1c(csc1C#N)[C@H]1CN2CCN(C[C@H]2CO1)C(=O)C1CCCc2cc(ccc12)-n1cnnn1

InChI Key InChIKey=UKOOYFCCHJMKRO-AVAATZNPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 290112   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM290112(US9573961, Example 97)
Affinity DataIC50:  620nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent