BDBM29033 cyanohydroxybutenamide, 23

SMILES CC(=O)C(C#N)C(=O)Nc1ccc(cc1C(F)(F)F)-c1cccc(Cl)c1

InChI Key InChIKey=PVTZUVGOUCKWLU-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 29033   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM29033(cyanohydroxybutenamide, 23)
Affinity DataKi:  6.80E+3nM ΔG°:  -7.04kcal/mole IC50:  5.72E+4nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Leeds

LigandPNGBDBM29033(cyanohydroxybutenamide, 23)
Affinity DataKi:  1.07E+4nM IC50:  8.66E+4nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed