BDBM291877 8-(1-cyclopropyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 192::US9580437, Example 192

SMILES Fc1ccc2OCCc2c1CNc1ncc(-c2ccnn2C2CC2)c2nncn12

InChI Key InChIKey=DRICLSBQZNGRNU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291877   

LigandPNGBDBM291877(8-(1-cyclopropyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3...)
Affinity DataIC50:  3.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291877(8-(1-cyclopropyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3...)
Affinity DataIC50:  12.6nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291877(8-(1-cyclopropyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3...)
Affinity DataIC50:  10.4nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291877(8-(1-cyclopropyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3...)
Affinity DataIC50:  3.5nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM291877(8-(1-cyclopropyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3...)
Affinity DataIC50:  12.6nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM291877(8-(1-cyclopropyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3...)
Affinity DataIC50:  10.4nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent