BDBM294927 2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(4-methoxypyrimidin-2-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole::US9586962, Example 483::US9586962, Example 484

SMILES COc1ccnc(n1)-c1cccc(F)c1C(=O)N1CC2CN(CC2C1)c1nc(C)cc(C)n1

InChI Key InChIKey=DVPCTIRPUBYLLP-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 294927   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294927(2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(4-m...)
Affinity DataKi:  11nM ΔG°:  -10.8kcal/moleT: 2°CAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294927(2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(4-m...)
Affinity DataKi:  230nM ΔG°:  -9.05kcal/moleT: 2°CAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294927(2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(4-m...)
Affinity DataKi:  284nM ΔG°:  -8.92kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM294927(2-(4,6-Dimethylpyrimidin-2-yl)-5-{[2-fluoro-6-(4-m...)
Affinity DataKi:  2.40E+3nM ΔG°:  -7.66kcal/moleT: 2°CAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent