BDBM295245 3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyridin-3-yl)-N-(3-hydroxy-3-methyl butyl)-4-methylbenzenesulfonamide::US10112926, Example 105

SMILES Cc1nnc(s1)-c1cc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCCC(C)(C)O

InChI Key InChIKey=WVPLMQRDKYAYCC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 295245   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295245(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Affinity DataIC50:  1.30E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295245(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Affinity DataIC50:  7.60E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295245(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Affinity DataIC50:  680nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295245(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Affinity DataIC50:  2.90E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295245(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Affinity DataIC50:  9.40nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM295245(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent