BDBM299181 N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-indazol-5-amine::US10125144, Example 9::US11311541, Example 189

SMILES Fc1ccc2CN(Cc2c1)c1nccc(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=PPRQSCUSEPEPNV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 299181   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299181(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Affinity DataIC50:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299181(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Affinity DataIC50:  2.93E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299181(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Affinity DataIC50:  40nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE™ Kinase Assay Kit (Invitrogen catalog number PV3793). Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM299181(N-(2-(5-Fluoroisoindolin-2-yl)pyrimidin-4-yl)-1H-i...)
Affinity DataIC50:  2.93E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent