BDBM304154 2-(1-((4- carboxyphenyl)amino)-3- cyclopropyl-1-oxobutan-2- yl)-5-(3-chloro-6- (difluoromethoxy)-2- fluorophenyl)pyridine 1- oxide::US10143681, Example 57::US10143681, Example 58::US10143681, Example 59::US10143681, Example 60

SMILES CC(C(C(=O)Nc1ccc(cc1)C(O)=O)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1OC(F)F)C1CC1

InChI Key InChIKey=LIUTYTAYTUGTHA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 304154   

TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304154(2-(1-((4- carboxyphenyl)amino)-3- cyclopropyl-1-ox...)
Affinity DataIC50: >1.00E+3nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304154(2-(1-((4- carboxyphenyl)amino)-3- cyclopropyl-1-ox...)
Affinity DataIC50:  62nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304154(2-(1-((4- carboxyphenyl)amino)-3- cyclopropyl-1-ox...)
Affinity DataIC50:  286nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM304154(2-(1-((4- carboxyphenyl)amino)-3- cyclopropyl-1-ox...)
Affinity DataIC50:  334nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent