BDBM312061 N-{3-Carbamoyl-1-[4-(methylsulfamoyl)phenyl]-1H-pyrazol-4-yl}-5-piperazin-1-ylpyrazolo[1,5-a]pyrimidine-3-carboxamide::US9649308, Example 33

SMILES CNS(=O)(=O)c1ccc(cc1)-n1cc(NC(=O)c2cnn3ccc(nc23)N2CCNCC2)c(n1)C(N)=O

InChI Key InChIKey=HFRAMSOSWXJNHG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312061   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312061(N-{3-Carbamoyl-1-[4-(methylsulfamoyl)phenyl]-1H-py...)
Affinity DataIC50:  4nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent