BDBM312821 1-[3-cyano-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-pyrroli- din-3-yl]ethynyl]phenyl] pyrazolo[3,4-b]pyridine-3- carboxamide::US9605005, Example 111

SMILES CN1CC[C@@](O)(C#Cc2cc(cc(c2)-n2nc(C(N)=O)c3cccnc23)C#N)C1=O

InChI Key InChIKey=ZOTMWAXVCBVWLO-NRFANRHFSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312821   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM312821(1-[3-cyano-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Affinity DataKi:  4.86nMAssay Description:The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent