BDBM317013 US9617267, Compound P-2001::US9617267, Compound P-2002::US9617267, Compound P-2003::US9617267, Compound P-2004::US9617267, Compound P-2005::US9617267, Compound P-2006::US9617267, Compound P-2007::US9617267, Compound P-2008::US9617267, Compound P-2012::US9617267, Compound P-2013::US9617267, Compound P-2015

SMILES CCCS(=O)(=O)Nc1ccc(F)c(C=O)c1F

InChI Key InChIKey=RWAQKKCELAQLHO-UHFFFAOYSA-N

Data  99 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 99 hits for monomerid = 317013   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50:  7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <5.00E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <5.00E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50:  7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50:  7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 1A2(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: <5.00E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Plexxikon

US Patent
LigandPNGBDBM317013(US9617267, Compound P-2001 | US9617267, Compound P...)
Affinity DataIC50:  7.50E+3nMAssay Description:The inhibition of CYP enzyme activity (IC50) for each of CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4(BFC) and CYP3A4(BQ) is determined for compounds, whe...More data for this Ligand-Target Pair
In DepthDetails US Patent
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