BDBM318016 8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-yl]-3,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-4-one::US9624218, Example 10

SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318016   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318016(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Affinity DataIC50:  158nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318016(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Affinity DataIC50:  3.37E+4nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM318016(8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-...)
Affinity DataIC50:  121nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent