BDBM321044 4-Amino-5-[2-(2-ethoxy-6-fluoro-phenyl)ethynyl]-7-[(2R,4S,5R)-4-hydroxy-5-[(sulfamoylamino)methyl]tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine::US10174040, Example 127::US9963456, Example 127

SMILES CCOc1cccc(F)c1C#Cc1cn([C@H]2C[C@H](O)[C@@H](CNS(N)(=O)=O)O2)c2ncnc(N)c12

InChI Key InChIKey=BXBUFFXQKGSKKI-CGTJXYLNSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 321044   

TargetNEDD8-conjugating enzyme UBE2F(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321044(4-Amino-5-[2-(2-ethoxy-6-fluoro-phenyl)ethynyl]-7-...)
Affinity DataIC50:  19nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321044(4-Amino-5-[2-(2-ethoxy-6-fluoro-phenyl)ethynyl]-7-...)
Affinity DataIC50:  340nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321044(4-Amino-5-[2-(2-ethoxy-6-fluoro-phenyl)ethynyl]-7-...)
Affinity DataIC50:  340nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent