BDBM341146 US9765057, 13::methyl 4-cyclopropyl-2-{[(3R,6R)-6- methyl-1-{[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3- yl]oxy}pyridine-3-carboxylate

SMILES COC(=O)c1c(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)nccc1C1CC1

InChI Key InChIKey=XYCSGJFINXFAAK-SJLPKXTDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 341146   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341146(US9765057, 13 | methyl 4-cyclopropyl-2-{[(3R,6R)-6...)
Affinity DataIC50:  803nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM341146(US9765057, 13 | methyl 4-cyclopropyl-2-{[(3R,6R)-6...)
Affinity DataIC50:  530nMAssay Description:FLIPR Ca2+ Flux Assay (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonistic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent