BDBM341243 (S)-4-(2-(1-(2,6-diamino-5-cyanopyrimidin-4-yl)pyrrolidin-2-yl)-4-oxo-3-phenyl-3,4-dihydroquinazolin-5-yl)butanoic acid ::US9765060, Compound 70

SMILES Nc1nc(N)c(C#N)c(n1)N1CCC[C@H]1c1nc2cccc(CCCC(O)=O)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=WDKDKOGDFAMTQW-FQEVSTJZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341243   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM341243((S)-4-(2-(1-(2,6-diamino-5-cyanopyrimidin-4-yl)pyr...)
Affinity DataIC50:  3nMAssay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent