BDBM349530 US10207991, Ex. Cpd. No. 46::US10611728, Example Compound 46::US11691947, Example 46
SMILES COC[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(F)cc2C1
InChI Key InChIKey=GAVBLSFCTDBORN-KRWDZBQOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 349530
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics
US Patent
Cognition Therapeutics
US Patent
Affinity DataKi: 94nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics
US Patent
Cognition Therapeutics
US Patent
Affinity DataKi: 94nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Cognition Therapeutics
US Patent
Cognition Therapeutics
US Patent
Affinity DataKi: 94nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics
US Patent
Cognition Therapeutics
US Patent
Affinity DataKi: 94nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cognition Therapeutics
US Patent
Cognition Therapeutics
US Patent
Affinity DataIC50: 1.60E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair