BDBM350338 (S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)-8-fluoroisoquinolin-3-yl)-1H-1,2,4-triazol-5(4H)-one::US10307414, Example 22::US9801872, Example 22

SMILES Fc1cccc2cc(nc(O[C@H]3CCN(C3)C(=O)C=C)c12)-c1n[nH]c(=O)[nH]1

InChI Key InChIKey=PBGDMHNPFLCLEA-NSHDSACASA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 350338   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350338((S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)-8-fluoro...)
Affinity DataIC50: <1.26nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM350338((S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)-8-fluoro...)
Affinity DataIC50: <1.26nMAssay Description:The inhibitory properties of compounds relative to BTK is determined using a black 384-well-plate format in a buffer which contains 50 mM Hepes, 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent