BDBM357844 US10214535, Example 4::methyl 2-cyano-6-{[(3R,6S)-6- (hydroxymethyl)-1-{[2-(2H- 1,2,3-triazol-2-yl)phenyl] carbonyl}piperidin-3-yl]oxy} benzoate

SMILES COC(=O)c1c(O[C@@H]2CC[C@@H](CO)N(C2)C(=O)c2ccccc2-n2nccn2)cccc1C#N

InChI Key InChIKey=HQHHLPAQBPGYPZ-ZWKOTPCHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357844   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357844(US10214535, Example 4 | methyl 2-cyano-6-{[(3R,6S)...)
Affinity DataIC50:  1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357844(US10214535, Example 4 | methyl 2-cyano-6-{[(3R,6S)...)
Affinity DataIC50:  49nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent