BDBM369940 (R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-3-methyl-1-oxobutan-2-yl)-2-fluoro-5-(trifluoromethyl)benzamide::US10233182, Example 52

SMILES CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]ncc2c1

InChI Key

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 369940   

LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: <500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysophosphatidic acid receptor 3(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  7nMAssay Description:Inhibition of autotaxin in mouse plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  14nMAssay Description:Inhibition of autotaxin in human plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG by GLP based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ENPP1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 2(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of LPAR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM369940((R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-di...)
Affinity DataIC50:  55nMAssay Description:Inhibition of C-terminal FLAG-tagged human autotaxin expressed in Freestyle 293 cells assessed as reduction in choline release from LPC 16:0 pre-incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed