BDBM373709 US10246444, Example 86

SMILES OC[C@H](O)COc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)C[C@H]1CCSS1

InChI Key InChIKey=KVMBBUXCOHWOBJ-XZOQPEGZSA-N

Data  3 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 373709   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373709(US10246444, Example 86)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373709(US10246444, Example 86)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [T790M,L858R](Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373709(US10246444, Example 86)
Affinity DataKd: >1.00E+4nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373709(US10246444, Example 86)
Affinity DataIC50:  550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-751,753-758,760-1210](Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373709(US10246444, Example 86)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [L858R](Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373709(US10246444, Example 86)
Affinity DataIC50:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373709(US10246444, Example 86)
Affinity DataIC50:  550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor [1-745,747-749,751-1210](Homo sapiens (Human))
Sabila Biosciences

US Patent
LigandPNGBDBM373709(US10246444, Example 86)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent