BDBM374601 2-[3-(3-amino-7-pyridin-3-yl-1H-indazol-5-yl)-2-(hydroxymethyl)phenyl]-6-tert-butyl-8-fluorophthalazin-1(2H)-one::US10246457, Example 10

SMILES CC(C)(C)c1cc(F)c2c(cnn(-c3cccc(-c4cc(-c5cccnc5)c5[nH]nc(N)c5c4)c3CO)c2=O)c1

InChI Key InChIKey=OHTFGPXAMMMEJJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374601   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM374601(2-[3-(3-amino-7-pyridin-3-yl-1H-indazol-5-yl)-2-(h...)
Affinity DataIC50:  299nMAssay Description:Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM374601(2-[3-(3-amino-7-pyridin-3-yl-1H-indazol-5-yl)-2-(h...)
Affinity DataIC50:  0.800nMAssay Description:Btk enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (lime-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent