BDBM384908 (S)- or (R)-2-(dimethylamino)-N-{1-[2- fluoro-4-(pentafluoro-lambda6-sulfanyl) phenyl]-2,2-dimethylpropyl}-6-oxo- 1,6-dihydropyrimidine-4-carboxamide::US10285989, Example 127::US10285989, Example 128

SMILES CN(C)c1nc(cc(=O)[nH]1)C(=O)NC(c1ccc(cc1F)S(F)(F)(F)(F)F)C(C)(C)C

InChI Key

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 384908   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384908((S)- or (R)-2-(dimethylamino)-N-{1-[2- fluoro-4-(p...)
Affinity DataKi:  0.150nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384908((S)- or (R)-2-(dimethylamino)-N-{1-[2- fluoro-4-(p...)
Affinity DataKi:  0.220nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM384908((S)- or (R)-2-(dimethylamino)-N-{1-[2- fluoro-4-(p...)
Affinity DataKi:  527nMAssay Description:The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent