BDBM385442 4-{(6R or S)-6-{[6- (tert-butoxycarbonyl)- 2,6-diazaspiro[3.3]hept- 2-yl]carbonyl}-1-[(2- chloro-6- cyclopropylphenyl) carbonyl]-4,5,6,7- tetrahydro-1H-indazol- 3-yl}cyclohex-3-ene-1- carboxylic acid::US10287272, Example 2YY::US10689369, Example 2YY

SMILES CC(C)(C)OC(=O)N1CC2(C1)CN(C2)C(=O)C1CCc2c(C1)n(nc2C1=CCC(CC1)C(O)=O)C(=O)c1c(Cl)cccc1C1CC1

InChI Key InChIKey=UGUHXAGSKUUZHG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385442   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385442(4-{(6R or S)-6-{[6- (tert-butoxycarbonyl)- 2,6-dia...)
Affinity DataIC50:  3nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385442(4-{(6R or S)-6-{[6- (tert-butoxycarbonyl)- 2,6-dia...)
Affinity DataIC50:  3nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent