BDBM385466 (R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoromethyl) cyclopropyl)benzoyl)-6- (((4-fluoropiperidin-4- yl)methyl)carbamoyl)- 4,5,6,7-tetrahydro-1H- indazol-3-yl)cyclohex-3- ene-1-carboxylic acid::US10287272, Example 5K::US10689369, Example 5K

SMILES OC(=O)C1CCC(=CC1)c1nn(C(=O)c2c(Cl)cccc2C2(CC2)C(F)(F)F)c2CC(CCc12)C(=O)NCC1(F)CCNCC1

InChI Key InChIKey=YNVLELUBMTZTDL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 385466   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385466((R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoro...)
Affinity DataIC50:  65nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM385466((R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoro...)
Affinity DataIC50:  65nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent