BDBM385466 (R or S)-4-((R or S)-1- (2-chloro-6-(1- (trifluoromethyl) cyclopropyl)benzoyl)-6- (((4-fluoropiperidin-4- yl)methyl)carbamoyl)- 4,5,6,7-tetrahydro-1H- indazol-3-yl)cyclohex-3- ene-1-carboxylic acid::US10287272, Example 5K::US10689369, Example 5K
SMILES OC(=O)C1CCC(=CC1)c1nn(C(=O)c2c(Cl)cccc2C2(CC2)C(F)(F)F)c2CC(CCc12)C(=O)NCC1(F)CCNCC1
InChI Key InChIKey=YNVLELUBMTZTDL-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 385466
Affinity DataIC50: 65nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair