BDBM388666 (S)-5-(4-(2-(4-chlorobenzyl)-4-methylpiperazin-1-yl)piperidin-1-yl)-4H-1,2,4-triazol-3-amine ::US10538508, Example 28::US9944624, Ex. 28

SMILES CN1CCN(C(Cc2ccc(Cl)cc2)C1)C1CCN(CC1)c1nnc(N)[nH]1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 388666   

TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388666((S)-5-(4-(2-(4-chlorobenzyl)-4-methylpiperazin-1-y...)
Affinity DataIC50:  550nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388666((S)-5-(4-(2-(4-chlorobenzyl)-4-methylpiperazin-1-y...)
Affinity DataIC50:  5.50E+4nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388666((S)-5-(4-(2-(4-chlorobenzyl)-4-methylpiperazin-1-y...)
Affinity DataIC50:  550nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM388666((S)-5-(4-(2-(4-chlorobenzyl)-4-methylpiperazin-1-y...)
Affinity DataIC50:  5.50E+4nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent