BDBM390729 (R)-N-(3-Aminochroman-7-yl)-1-methyl-5-(thiophen-2-yl)-1H-pyrazole-3-carboxamide::US9957261, Example 85

SMILES Cn1nc(cc1-c1cccs1)C(=O)Nc1ccc2C[C@@H](N)COc2c1

InChI Key InChIKey=YNGPUVDTNILCCC-GFCCVEGCSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390729   

TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390729((R)-N-(3-Aminochroman-7-yl)-1-methyl-5-(thiophen-2...)
Affinity DataKi:  0.900nMAssay Description:Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Hoffmann-La Roche

US Patent
LigandPNGBDBM390729((R)-N-(3-Aminochroman-7-yl)-1-methyl-5-(thiophen-2...)
Affinity DataKi:  6.10nMAssay Description:Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent