BDBM400823 QL-XII-47-AL::US10000483, Compound II-20

SMILES CN(C\C=C\CN1CCc2ccc(cc12)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnn(C)c1)CC#C

InChI Key InChIKey=VJDVKRQPRSCAPE-AATRIKPKSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400823   

TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM400823(QL-XII-47-AL | US10000483, Compound II-20)
Affinity DataIC50:  479nMAssay Description:Purified BMX was mixed with substrate (FAK or Bmxtides), kinase buffer (final 20 mM HEPES, pH 7.5, 10 mM MgCl2, 20 mM β-glycerophosphate, 1 mM d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM400823(QL-XII-47-AL | US10000483, Compound II-20)
Affinity DataIC50:  479nMAssay Description:DiscoverX binding assays were performed according to published methods (Fabian et al., Nat. Biotechnol. 23, 329-36 (2005); Davis et al., Nat. Biotech...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM400823(QL-XII-47-AL | US10000483, Compound II-20)
Affinity DataIC50:  641nMAssay Description:DiscoverX binding assays were performed according to published methods (Fabian et al., Nat. Biotechnol. 23, 329-36 (2005); Davis et al., Nat. Biotech...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent