BDBM414505 N-Ethyl-N-{2-[4-(1-hydroxy-1-methylpropyl)-5-methyl-1,3-oxazol-2-yl]ethyl}-2-(2H-1,2,3-triazol-2-yl)benzamide::US10435398, Example 19::US10435398, Example 20

SMILES CCN(CCc1nc(C(=O)N(C)OC)c(C)o1)C(=O)c1ccccc1-n1nccn1

InChI Key InChIKey=RNKBQPJSTOLGKU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 414505   

TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414505(N-Ethyl-N-{2-[4-(1-hydroxy-1-methylpropyl)-5-methy...)
Affinity DataIC50:  12nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414505(N-Ethyl-N-{2-[4-(1-hydroxy-1-methylpropyl)-5-methy...)
Affinity DataIC50:  2.67E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414505(N-Ethyl-N-{2-[4-(1-hydroxy-1-methylpropyl)-5-methy...)
Affinity DataIC50:  19nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414505(N-Ethyl-N-{2-[4-(1-hydroxy-1-methylpropyl)-5-methy...)
Affinity DataIC50:  3.38E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent