BDBM436584 (R)-2,9-dimethyl-6-(3- ((3-(methylamino)-1- (thiophen-2-yl) propoxy)methyl) phenyl)-6,7,8,9- tetrahydro-5H- pyrimido[4,5-e][1,4] diazepin-5-one::US10590140, Example 360

SMILES CNCC[C@@H](OCc1cccc(c1)N1CCN(C)c2nc(C)ncc2C1=O)c1cccs1

InChI Key InChIKey=DDWJAWDHKATTEZ-OAQYLSRUSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436584   

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103](Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM436584((R)-2,9-dimethyl-6-(3- ((3-(methylamino)-1- (thiop...)
Affinity DataKi:  300nMAssay Description:α2δ-1: Binding Assay to Human α2δ-1 Subunit of Cav2.2 Calcium Channel.Human α2δ-1 enriched membranes (2.5 μg) were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1 [25-1103](Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM436584((R)-2,9-dimethyl-6-(3- ((3-(methylamino)-1- (thiop...)
Affinity DataKi:  300nMAssay Description:α2δ-1: Binding Assay to Human α2δ-1 Subunit of Cav2.2 Calcium Channel.Human α2δ-1 enriched membranes (2.5 μg) were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM436584((R)-2,9-dimethyl-6-(3- ((3-(methylamino)-1- (thiop...)
Affinity DataKi:  300nMAssay Description:NET: Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent