BDBM49766 MLS000708948::N-(3-imidazol-1-ylpropyl)-5-phenyl-1,2-oxazole-3-carboxamide::N-(3-imidazol-1-ylpropyl)-5-phenyl-isoxazole-3-carboxamide::N-[3-(1-imidazolyl)propyl]-5-phenyl-3-isoxazolecarboxamide::SMR000289715::cid_2962284

SMILES O=C(NCCCn1ccnc1)c1cc(on1)-c1ccccc1

InChI Key InChIKey=FLWZIODGHJAZJD-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 49766   

TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM49766(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Affinity DataEC50:  7.72E+3nMAssay Description:Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM49766(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Affinity DataEC50:  1.58E+4nMAssay Description:Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM49766(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Affinity DataEC50:  6.75E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTranscription factor p65(Homo sapiens (Human))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM49766(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Affinity DataEC50:  1.37E+6nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
The Broad Institute Probe Development Center

Curated by ChEMBL
LigandPNGBDBM49766(MLS000708948 | N-(3-imidazol-1-ylpropyl)-5-phenyl-...)
Affinity DataEC50:  8.67E+3nMAssay Description:Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed