BDBM50007568 1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine::1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-4-methyl-piperazine::CHEMBL303313::OCTOCLOTHEPIN-S
SMILES CN1CCN(CC1)[C@H]1Cc2ccccc2Sc2ccc(Cl)cc12
InChI Key InChIKey=XRYLGRGAWQSVQW-KRWDZBQOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 31 hits for monomerid = 50007568
Affinity DataKi: 0.00900nMAssay Description:Displacement of [3H]prozosin from hamster cloned alpha1b receptorMore data for this Ligand-Target Pair
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 0.0760nMAssay Description:Displacement of [3H]prozosin from rat cloned alpha1d receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.220nMAssay Description:Displacement of [3H]prazosin (0.5 nM) from hamster Alpha-1B adrenergic receptor expressed in rat-1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.280nMAssay Description:Displacement of [3H]prozosin from bovine cloned alpha1a receptor expressed in BHK cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:In vitro binding affinity towards Dopamine receptor D3 in Sf9 cell membranes using [3H]7-OH-DPAT as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Half-maximal inhibition of [3H]-7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 0.560nMAssay Description:Displacement of [3H]prazosin (0.3 nM) from bovine Alpha-1A adrenergic receptor expressed in BHK cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]prozosin from human cloned dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]-YM-09151-2 (0.06 nM) from human Dopamine receptor D4 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]prozosin from human cloned 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Displacement of [3H]prozosin from human cloned histamine H1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.480nMAssay Description:Ability to inhibit binding of [3H]KET to 5-hydroxytryptamine 2 receptor in rat cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Ability to displace [3H]spiperone (0.5 nM) from corpus striatum of rat Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1More data for this Ligand-Target Pair
Affinity DataIC50: 0.480nMAssay Description:Ability to displace [3H]ketanserin (0.5 nM) from cerebral cortex of rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
H. Lundbeck
Curated by ChEMBL
H. Lundbeck
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Ability to inhibit binding of [3H]PRAZ to alpha-1 adrenergic receptor in rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Binding affinity against Dopamine receptor D2 using [3H]spiroperidolMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding affinity at dopamine D2 receptor by [3H]-Spiperone displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Binding affinity towardst dopamine D2 receptor by displacement of [3H]-SPI radioligand in rat striatal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Ability to inhibit binding of [3H]-SPI to dopamine receptor D2 in rat striatal membranesMore data for this Ligand-Target Pair